mapscape - mapscape
MapScape integrates clonal prevalence, clonal hierarchy,
anatomic and mutational information to provide interactive
visualization of spatial clonal evolution. There are four
inputs to MapScape: (i) the clonal phylogeny, (ii) clonal
prevalences, (iii) an image reference, which may be a medical
image or drawing and (iv) pixel locations for each sample on
the referenced image. Optionally, MapScape can accept a data
table of mutations for each clone and their variant allele
frequencies in each sample. The output of MapScape consists of
a cropped anatomical image surrounded by two representations of
each tumour sample. The first, a cellular aggregate, visually
displays the prevalence of each clone. The second shows a
skeleton of the clonal phylogeny while highlighting only those
clones present in the sample. Together, these representations
enable the analyst to visualize the distribution of clones
throughout anatomic space.